Livmarli receives Health Canada authorization for Alagille syndrome – Mirum Pharmaceuticals

Health Canada has authorized the use of maralixibat oral solution (Livmarli) for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS), as recently announced by Mirum Pharmaceuticals.

Health Canada’s authorization is based on data from the pivotal ICONIC study, which includes 6 years of data from the maralixibat clinical program. The study has provided robust evidence demonstrating statistically significant and clinically meaningful reductions in pruritus vs placebo, along with significant and durable reductions in serum bile acids.