Alnylam to present new analyses at Heart Failure 2026 underscoring consistent clinical profile of Vutrisiran in ATTR-CM

Alnylam Pharmaceuticals, Inc announced it will present new data analyses for vutrisiran in patients with the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) at Heart Failure 2026, a scientific congress of the European Society of Cardiology, taking place May 9-12, 2026, in Barcelona, Spain.

ATTR-CM is a heterogeneous and rapidly progressive disease, and patients often present with complex clinical profiles. At Heart Failure 2026, Alnylam will present multiple new analyses from the Phase 3 HELIOS-B study of vutrisiran, which continue to support its use as a first-line treatment for patients with ATTR-CM, and further characterize its clinical profile across patients with a high disease burden, and in the context of concomitant therapies. Vutrisiran is the first and only transthyretin (TTR) silencer for ATTR-CM that delivers rapid knockdown of TTR at the source.

Additional analyses being presented at the congress include a pharmacodynamic analysis of TTR knockdown with vutrisiran across subgroups, a pooled safety analysis evaluating the incidence of TTR lowering with vitamin-A-related outcomes across clinical trial and real-world datasets, as well as the design of DemonsTTRate, a global, long-term observational study evaluating real-world use in patients with ATTR-CM.

Presentation Details

Design and Rationale of DemonsTTRate: A Global, Long-Term Observational Study to Evaluate Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
Session: Evolving management of cardiomyopathies: early detection, precision diagnostics, and emerging treatments (Moderated ePosters 3)
Sunday, May 10, 08:30 – 09:15 CEST, 2:30 – 3:15 A.M. EST
Presenting Author: Pablo Garcia-Pavia, Spain

Influence of Vutrisiran on Systolic Blood Pressure in ATTR-CM: Insights From HELIOS-B
Session: Cardiac amyloidosis: therapeutic strategies and clinical outcomes (Moderated ePosters 4)
Sunday, May 10, 15:30 – 16:15 CEST, 9:30 – 10:15 A.M. EST
Presenting Author: Awais Sheikh, United Kingdom

Effect of Vutrisiran in Patients with and without Atrial Fibrillation or Flutter: Analysis from HELIOS-B
Session: Advances in amyloidosis and hypertrophic cardiomyopathy: from diagnosis to treatment (Moderated ePosters 2)
Monday, May 11, 10:30 – 11:15 CEST, 4:30 – 5:15 A.M. EST
Presenting Author: Xiaowen Wang, United States of America

Treatment with Transthyretin-Lowering RNA Interference Therapeutics is Not Associated with Ocular or Other Clinical Events Due to Vitamin A Reduction: Pooled Analysis of Vutrisiran and Patisiran Data
Session: Advances in amyloidosis and hypertrophic cardiomyopathy: from diagnosis to treatment (Moderated ePosters 2)
Monday, May 11, 10:30 – 11:15 CEST, 4:30 – 5:15 A.M. EST
Presenting Author: Mathew Maurer, United States of America

Vutrisiran-Mediated Knockdown of Transthyretin in Patients with Transthyretin Amyloidosis
Session: Transthyretin amyloidosis: long-term outcomes and emerging therapies (Rapid Fire Abstracts)
Monday, May 11, 16:45 – 17:45 CEST, 10:45 – 11:45 A.M. EST
Presenting Author: Vincent Algalarrondo, France

Influence of Disease-Modifying Therapy on the Effectiveness of Vutrisiran in Transthyretin Cardiac Amyloidosis
Session: Transthyretin amyloidosis: long-term outcomes and emerging therapies (Rapid Fire Abstracts)
Monday, May 11, 16:45 – 17:45 CEST, 10:45 – 11:45 A.M. EST
Presenting Author: Arielle Abovich, United States of America

Consistent Efficacy of Vutrisiran Across Sexes in ATTR-CM, HELIOS-B Trial –Prespecified Sex Analysis
Session: Transthyretin amyloidosis: long-term outcomes and emerging therapies (Rapid Fire Abstracts)
Monday, May 11, 16:45 – 17:45 CEST, 10:45 – 11:45 A.M. EST
Presenting Author: Josephine Mansell, United Kingdom

Comorbidity Burden in Transthyretin Amyloidosis With Cardiomyopathy: Insights From the HELIOS-B Trial
Session: Risk factors and comorbidities (Moderated ePosters 3)
Tuesday, May 12, 08:30 to 09:15 CEST, 2:30 – 3:15 A.M. EST
Presenting Author: Sarah Birkhoelzer, United Kingdom

AMVUTTRA® (vutrisiran) INDICATIONS AND IMPORTANT SAFETY INFORMATION

Indications
In the EU, AMVUTTRA® (vutrisiran) is indicated for the treatment of:

• hereditary transthyretin amyloidosis in adult patients with stage 1 or stage 2 polyneuropathy (hATTR-PN).
• wild-type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy (ATTR-CM).

Availability across the EU is subject to local reimbursement timelines.