Intellia Therapeutics to show three-year lonvo-z durability data in hereditary angioedema at AAAAI 2026

Intellia Therapeutics Presents Longer-Term Clinical Data for Lonvoguran Ziclumeran (lonvo-z); Hereditary Angioedema (HAE) Patient-Focused Research at AAAAI 2026.

Presentations include three-year follow-up data from patients receiving a one-time 50 milligram (mg) dose of lonvo-z and survey findings highlighting patients’ continued treatment burden and unmet needs.

Details about thepresentation of four posters at the 2026 American Academy of Allergy, Asthma & Immunology Annual Meeting (AAAAI) that took place this past weekend in Philadelphia, Pennsylvania. All posters are available on intelliatx.com on the Scientific Publications & Presentations page.

Title: Long-Term Durability and Safety of Lonvoguran Ziclumeran (Lonvo-z; NTLA-2002) 50 mg in Patients with Hereditary Angioedema

Session: Allergic Skin Diseases

Poster Number: 061

Presenter: Markus Magerl, M.D, Professor, Head of Clinical Trials, Charité – Universitätsmedizin Berlin Institute of Allergology

• In this pooled Phase 1/2 analysis (n=32), a one-time 50 mg dose of lonvo-z led to deep, stable and durable reductions in plasma kallikrein across all patients with up to three years of follow-up.
• Across the 32 patients, the mean monthly attack rate was consistently ≤0.2, representing a mean reduction of 96% in HAE attacks from baseline through last follow-up. Of the 32 patients, 31 (97%) were both attack-free and LTP-free as of the data cutoff, with the attack-free and LTP-free periods ranging from 2 months to 3 years with follow-up ongoing.

Title: Evolving Treatment Goals to Achieve Freedom from Attacks and Long-Term Prophylaxis Following a One-Time Treatment with Lonvoguran Ziclumeran (Lonvo-z; NTLA-2002)
Session: Allergic Skin Diseases
Poster Number: 005
Presenter: Aleena Banerji, M.D., Professor at Harvard Medical School, Clinical Director of the Allergy and Clinical Immunology Unit at Massachusetts General Hospital

• Recent research shows that achieving an attack-free status and simultaneously minimizing treatment burden are primary treatment goals for HAE experts and patients.
• Of the 28 patients with >6 months of follow-up after receiving a one-time 50 mg treatment of lonvo-z in a pooled Phase 1/2 analysis, 86% were attack-free and LTP-free for >6 months, a timeframe suggested by patients to be clinically meaningful.

Title: Quantitative Systems Biology Modeling Estimates Extent of Excessive Kallikrein Generation in Hereditary Angioedema Patients
Session: Allergic Skin Diseases
Poster Number: 003
Presenter: Allen Kaplan, M.D., Professor, Department of Medicine, Medical University of South Carolina

• This model suggested that HAE with significant C1-esterase inhibitor deficiency generates excess plasma kallikrein compared to healthy individuals, directly correlating with bradykinin increases.
• In this model, an 85% reduction in prekallikrein was shown to reduce peak free kallikrein and peak bradykin to near normal ranges. This level of reduction in prekallikrein is consistent with what has been observed clinically with a 50 mg dose of lonvo-z.

Title: Chronic Medications Pose Challenges for People Living with Hereditary Angioedema
Session: Bridging Evidence for Real World Impact
Poster Number: 716
Presenter: Paula Busse, M.D., Professor, Department of Medicine, Division of Clinical Immunology, Mount Sinai Hospital

• Among 100 surveyed U.S. patients with HAE, 89% of whom were on long-term prophylaxis therapies and 11% of whom were on on-demand therapies only, 34% reported having at least one attack per month and only 20% reported being attack free in the prior year.
• Most respondents indicated that eliminating lifetime chronic medication use and enhancing efficacy are the most important ways to improve their current therapy.