Travere Therapeutics to Present Key Data on FILSPARI™ (Sparsentan) in IgA Nephropathy and FSGS at ASN Kidney Week 2024

Travere Therapeutics, Inc.,  announced that the Company will present 11 abstracts, including one late-breaking abstract at the upcoming American Society of Nephrology (ASN) Kidney Week 2024 in San Diego, CA, October 23-27, 2024.

Presentations will include new data from the SPARTAN Study highlighting efficacy and safety results of FILSPARI (sparsentan) in IgA nephropathy (IgAN) when used as a first-line treatment in newly diagnosed IgAN patients, an analysis from the PROTECT Study examining the clinical benefit of FILSPARI in IgAN regardless of participants’ baseline proteinuria, as well as patient-reported outcomes from the PROTECT and DUPLEX Studies. The Company will also present new data from the SPARTACUS Study, PROTECT open label extension, and real-world clinical experience of FILSPARI in IgAN demonstrating improvements in proteinuria reduction along with safety and efficacy data of sparsentan when used in combination with SGLT2 inhibitors. The late-breaking presentation is a post hoc analysis of outcomes of participants with genetic focal segmental glomerulosclerosis (gFSGS) from the DUPLEX Study.

We look forward to presenting data from a growing body of evidence supportive of the clinical benefit in IgAN that FILSPARI can provide when used as a first-line treatment and in combination with other therapies,” said Jula Inrig, M.D., chief medical officer of Travere Therapeutics. “We’re also looking forward to presenting additional subgroup analyses from sparsentan in FSGS, where we will present data from a small group of high-risk patients with genetic FSGS, one of the most resistant to treatment.”

You can find more information on Travere’s presence at ASN here.

 

Late-Breaking Presentation

Outcomes of the DUPLEX Trial in Patients with Genetic Focal Segmental Glomerulosclerosis (gFSGS)
Poster: TH-PO1199
Session: Late-Breaking Science Posters
Exhibit Hall; October 24, 2024, from 10:00 a.m. to 12:00 p.m. PT

 

Oral Presentations

PROTECT Subgroup Analysis: Sparsentan Provides Clinical Benefits vs. Irbesartan in Patients with IgA Nephropathy (IgAN) with Proteinuria Above and Below 1 g/g
Oral: FR-OR57
Oral Abstract Session: IgA Nephropathy: New Therapies and Insights
Room 6D; October 25, 2024, 4:50–5:00 p.m. PT

Sparsentan as a First-Line Treatment of Incident Patients with IgA Nephropathy (IgAN): Interim Analysis of the SPARTAN Trial
Oral: FR-OR63
Oral Abstract Session: IgA Nephropathy: New Therapies and Insights
Room 6D; October 25, 2024, 5:40–5:50 p.m. PT

 

Poster Presentations

Sparsentan in Pediatric Patients with Rare Proteinuric Kidney Disease: Preliminary Findings from the EPPIK Study
Poster: TH-PO605
Poster Session: Membranous Nephropathy, FSGS, and Minimal Change Disease
Exhibit Hall; October 24, 2024, 10:00 a.m.–12:00 p.m. PT

Patient-Reported Outcomes in Adult Patients with Focal Segmental Glomerulosclerosis (FSGS): Sparsentan versus Irbesartan
Poster: TH-PO607
Poster Session: Membranous Nephropathy, FSGS, and Minimal Change Disease
Exhibit Hall; October 24, 2024, 10:00 a.m.–12:00 p.m. PT

Concomitant Sparsentan and Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2is) in Adults with IgA Nephropathy (SPARTACUS)
Poster: FR-PO849
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT

Concomitant Sparsentan and Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2is) in Patients with IgA Nephropathy (IgAN) in the PROTECT Open-Label Extension (OLE)
Poster: FR-PO851
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT

Patient-Reported Outcomes in the PROTECT Clinical Trial Comparing Sparsentan with Irbesartan for Immunoglobulin A Nephropathy
Poster: FR-PO868
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT

Implications of Proteinuria Remission on Estimated Glomerular Filtration Rare (eGFR) Trajectory in Patients with IgA Nephropathy (IgAN) in PROTECT
Poster: FR-PO872
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT

Sparsentan in Combination with a Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2i) and Steroid as First-Line Treatment for IgA Nephropathy (IgAN): A Case Report
Poster: FR-PO906
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT

Sparsentan in Patients with Prior or Concurrent Immunosuppressive Treatment (IST) for IgA Nephropathy (IgAN): A Case Series
Poster: FR-PO907
Poster Session: IgA Nephropathy: Clinical, Outcomes, and Therapeutics
Exhibit Hall; October 25, 2024, 10:00 a.m.–12:00 p.m. PT