Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors


High drug price associated with decreased treatment retention for patients with chronic liver disease

Written by | 30 Aug 2023 | Hepatology

Researchers from the University of Minnesota Medical School and College of Pharmacy have found that high costs for hepatic encephalopathy treatment in patients with end-stage liver disease were associated with decreased treatment retention for patients. The study results were recently published in Hepatology Communications.

Hepatic encephalopathy is the loss of brain function that occurs in people with severe liver disease. The condition is associated with high morbidity and mortality. The drug treatment rifaximin is commonly used to treat hepatic encephalopathy, yet treatment retention remains low.

“Our research demonstrates that the cost of rifaximin is too high in the United States. Individuals with scarred livers, who have a higher out-of-pocket cost, are more likely to not fill their prescription for their medication, which can result in falls, hospitalizations and other poor outcomes,” said Elizabeth Aby, MD, an assistant professor at the University of Minnesota Medical School and transplant hepatologist at M Health Fairview. “Clinicians and policy makers need to be aware of the impact that out-of-pocket costs have on patients’ medication adherence for rifaximin. Active measures must be taken to address this issue.”

The study included more than 6,800 patients with cirrhosis — a condition where the liver is scarred from long term damage — and hepatic encephalopathy. The research team’s analysis found patients who are younger and have metastatic cancer or depression are less likely to take their medication.

The research team suggests clinicians screen patients for financial insecurity and the potentially harmful effect the high cost of treatment could have on the patient, as well as involving social workers and financial assistance early. Additionally, further steps are needed to lower the cost of the drug.

Newsletter Icon

Subscribe for our mailing list

If you're a healthcare professional you can sign up to our mailing list to receive high quality medical, pharmaceutical and healthcare E-Mails and E-Journals. Get the latest news and information across a broad range of specialities delivered straight to your inbox.


You can unsubscribe at any time using the 'Unsubscribe' link at the bottom of all our E-Mails, E-Journals and publications.