EULAR 2020: Lilly shares new data for Olumiant in rheumatoid arthritis and systemic lupus erythematosus.

Eli Lilly and Company will present new data for Olumiant (baricitinib) at the virtual European Congress of Rheumatology (EULAR 2020) taking place June 3-6, 2020. Highlights from Olumiant data being presented at the virtual meeting include new long-term data in patients living with rheumatoid arthritis (RA) as well as data from an investigational trial in patients with systemic lupus erythematosus (SLE).

At this year’s meeting, Lilly will share results from a long-term study that evaluated the efficacy of Olumiant in patients with moderate to severe RA during three years of treatment. The study measured the achievement of clinically-relevant outcomes, including low disease activity (LDA) as measured by the simplified disease activity index (SDAI less than 11), in DMARD-naïve patients and patients with an inadequate response to methotrexate (MTX-IR) from treatment initiation to three years. Patients in this study were treated with Olumiant 4-mg once daily, an approved dose outside of North America. The study found that among patients with an inadequate response to MTX, 52% of patients initially treated with Olumiant (+MTX) were in a state of SDAI LDA at week 24 and this rate was maintained through week 148.

Lilly will also share an updated integrated safety analysis of Olumiant in the treatment of RA using data from 3,770 patients who were treated with the medicine for up to 8.4 years. The study found that Olumiant’s safety profile remains consistent with what has been previously reported, with no increase in the rates of safety topics of interest, including serious infections, herpes zoster, major adverse cardiovascular events, deep-vein thrombosis and/or pulmonary embolism, non-melanoma skin cancer (NMSC), and non-NMSC malignancies. No new safety signals were identified.

In addition, Lilly will present analyses from an investigational trial evaluating baricitinib in patients with SLE at EULAR. Data from its Phase II randomized, placebo-controlled, double-blind JAHH study will be highlighted, which observed whether or not SLE patients experienced changes in their serum cytokine levels when being treated with the 4-mg dose of baricitinib.