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Theravance Biopharma will share clinical insights on norepinephrine reuptake inhibitor ampreloxetine at AAS 2025
Theravance Biopharma, Inc announced that it will be participating at the 36th International Symposium on the Autonomic Nervous System, organized by the American Autonomic Society (AAS), taking place November 5-8, 2025, in Clearwater Beach, FL. The Company will have one platform presentation and three poster presentations on its clinical development program for ampreloxetine, a potential first-in-class norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension (nOH) symptoms due to multiple system atrophy (MSA).
“We are excited to have a strong presence at the upcoming International Symposium on the Autonomic Nervous System. Our platform presentation will highlight results from the previous REDWOOD trial, where we observed a durable symptomatic nOH benefit with improvement in activities of daily living in the pre-specified subgroup analysis in patients with MSA treated with ampreloxetine1,” commented Lucy Norcliffe-Kaufmann, Ph.D., Theravance Biopharma’s Executive Director of Clinical Science. “Additionally, we are pleased to share the rigorous methodologies we developed based on our previous trial experience to support enrollment and patient retention. By applying these insights, we were well positioned to successfully address the executional challenges associated with clinical studies in rare and severe neurodegenerative diseases.”
Presentations information and key findings:
Platform presentation: Precision therapy with ampreloxetine for neurogenic orthostatic hypotension in multiple system atrophy
Presenter: Lucy Norcliffe-Kaufmann, Ph.D.; Theravance Biopharma’s Executive Director of Clinical Science and Associate Professor, New York University Langone Health Dysautonomia Center
Session date and time: Saturday, November 8, 2025, at 8:30 am ET
The following three posters will be presented at Poster Session II, taking place on Thursday, November 6, 2025, at 7:00-8:30 pm ET:
Poster title: The impact of ampreloxetine on supine hypertension: an ambulatory blood pressure monitoring study
Presenter: Lucy Norcliffe-Kaufmann, Ph.D.; Theravance Biopharma’s Executive Director of Clinical Science and Associate Professor, New York University Langone Health Dysautonomia Center
Poster number: 9
Poster title: Retention strategies in rare disease clinical trials: a case study of symptomatic treatment for multiple system atrophy
Presenter: Molly Szpyhulsky, MBA, BSN, RN; Theravance Biopharma U.S.
Poster number: 15
Poster title: Enrollment strategies in a phase III trial for MSA-related nOH: insights from global investigators
Presenter: Molly Szpyhulsky, MBA, BSN, RN; Theravance Biopharma U.S.
Poster number: 10
